en تخصصي Special پژوهشي Research <strong><span new="" roman="" times=""><span style="font-weight:bold">We theoretically analyze the sensing properties of a one-dimensional photonic crystal-based biosensor for detecting cancer cells infiltrated in a defect cavity layer. The biosensor consists of a sample cavity layer sandwiched between two identical photonic crystals of <span advptimes="">Hgba₂Ca₂Cu₃O₈₊</span>_d and GaAs. We use the transfer matrix method to evaluate the performance of the biosensor. We show that a defect mode appears in the transmission spectrum of the biosensor that its position depends on the type of cancer cells in the cavity layer. The analysis is carried out by comparing the transmittance peaks of the cancer cells with the normal cells. We investigate the performance of the biosensor under different hydrostatic pressures and temperatures. We show that one can use temperature change to fine-tune the frequency of the defect modes. In addition, we can adjust the working area of the biosensor by changing the hydrostatic pressure. It is shown that the sensitivity of the biosensor is independent of the temperature, while it strongly depends on the hydrostatic pressure.</span></span></strong> biosensor, defect mode, hydrostatic pressure, photonic crystal, semiconductor, superconductor, temperature. 179 186 http://ijop.ir/browse.php?a_code=A-10-52-4&slc_lang=en&sid=1 Samad Roshan Entezar s-roshan@tabrizu.ac.ir 10031947532846003902 10031947532846003902 Yes Department of Physics, University of Tabriz, Tabriz, Iran